The South African National LGBTI HIV Plan, 2017-2022 (LGBTI HIV Plan) is a milestone in the country’s response to HIV, AIDS, STIs, and TB. A national, multi-sectoral effort to address the linked HIV, TB and STI epidemics among Lesbian, Gay, Bisexual, Trans* and Intersex (LGBTI) people is urgent and somewhat overdue. Due to HIV vulnerabilities that are unique to each sub-group, there is a need for a strategic document that focuses on the LGBTI groups to support the National Strategic Plan on HIV, STIs and TB 2017-2022.